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We develop breakthrough formulations of poorly soluble compounds and sensitive biologics at ambient temperature using our proprietary high-speed electrospinning technology. 

Our proprietary high-speed electrospinning technology utilizes both centrifugal and electrostatic forces for large-scale nano- or microfiber production.

By using our flexible pilot-scale GMP-compliant machine, 300-500 g solid product/h production rates can be achieved.

Key features and advantages of the technology include:

  • production of nanofibers or particles with ultrafast dissolution;

  • increased bioavailability of poorly soluble drugs by creating (nano)amorphous solid dispersions;

  • possibility of the drying of sensitive APIs at room temperature;

  • single-step production of formulations for special drug delivery routes (buccal, intranasal, transdermal, etc.);

  • scalability – rapid feasibility studies from 200 mg API to pilot-scale production.

GMP-compliant high-speed electrospinning equipment

The basics of electrospinning

Electrospinning is a continuous low-cost technology to generate dried fibers by utilizing the electrostatic forces on a liquid feed to turn it into ultrafine (normally <10 μm) fiber structures, which can dry instantly at room temperature during process operation.

The fiber-forming excipient (polymer or cyclodextrin, lipid, etc.) is dissolved in a solvent and the solution is fed into a single spinneret at a constant, controlled flow rate. High voltage is applied between the spinneret and the grounded collector. When the electrostatic forces overcome the surface tension, a liquid jet breaks out from the liquid surface and stabilizes between the nozzle and the collector as a continuous stream. During the process, the jets get elongated gaining a fiber-like structure. The solvent evaporates instantaneously at room temperature due to the high surface area, as the fibers are often submicron-sized. By using solutions with lower concentrations, it is possible to prepare spherical particles - this process is called electrospraying.

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