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Electrospinning

At Qdevelopment, we are set to offer design, development, and analytical services to translate electrospun constructs from ideas to scalable prototypes and products. Our proprietary high-speed electrospinning technology uses both centrifugal and electrostatic forces for large-scale nano- or microfiber production. The pharmaceutical industry has not been using the nanofiber spinning process yet although it would provide several benefits. Thanks to the huge surface area of the nanofibers and stabile amorphisation effect of the fast drying process nanofibrous materials have great potential in dissolution and bioavailibility enhancements and biodrug formulations. 

Scalable

  • production capacity from few mgs to several kgs

  • continuous nanofiber production

 

Flexible

  • flexibility in used

    • matrices (polymers, cyclodextrins, etc.) 

    • solvents (water and organic-based solvents) 

    • substrates

Modern pilot-scale device

  • different fiberizer heads

  • different innovative collector systems

  • user-friendly touch-screen interface

  • solvent recovery system

  • made of stainless steel and ATEX materials

  • simple maintenance

  • possibility to use under nitrogen atmosphere

Projects are tailored to fit your specific needs, executed by our skilled staff and are charged on a case by case basis. For more information on the services provided, please do not hesitate to contact us!

Large molecules/biopharmaceuticals
  • proteins (monoclonal antibodies, enzymes, hormones, etc.)

  • peptides, oligonucleotides, vaccines

  • whole cells

  • gentle drying at room temperature

  • continuous drying alternative to freeze drying

Small molecule drugs
  • continuous production of amorphous solid dispersions (ASDs)

  • preparation of supersaturated drug delivery systems

  • nano or microfibers with ultrafast dissolution

  • enhanced dissolution and bioavailability of poorly soluble drugs

  • downstream processing of the fibers to tablet/capsule formulation

Applications
  • Powders: oral (tablets, capsules, sachets), parenteral, nasal, pulmonar, ophtalmic, vaginal and topical applications

  • Orally disintegrating tablets (ODT) and orodispersible films (ODF)

  • Films and patches: buccal, sublingual, transdermal and mucosal applications

  • Innovative dosage forms (e.g. medicated straw - age-appropriate formulation)

References

info@qdevelopment.hu

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